Hormonal and Barrier Methods of Contraception, Oncogenic Human Papillomaviruses, and Cervical Squamous Intraepithelial Lesion Development

作者: Ann L. Coker , Laura C. Sanders , Sharon M. Bond , Tsilya Gerasimova , Lucia Pirisi

DOI: 10.1089/152460901300233911

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摘要: We assessed the influence of hormonal (oral, injectable, or levonorgestrel [Norplant, Wyeth-Ayerst, Philadelphia, PA]) and barrier methods contraception on risk cervical squamous intraepithelial lesions (SIL), while adjusting for high-risk (HR) HPV infection. Subjects were women receiving family planning services through state health department clinics from 1995 to 1998. selected 60 cases with high-grade cervical/SIL (HSIL) 316 low-grade (LSIL) controls (427 normal cytology) analyzed DNA HR-HPV, using Hybrid Capture I (Digene; Gaithersburg, MD). When assessing ever use, duration, recency, latency, age at first neither oral contraceptives (OC), Norplant, nor injectable use was associated an increased SIL development after age, sexual intercourse, HR-HPV positivity. Among HR-HPV-positive women, longer duration method a reduced SIL. This ...

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