USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

摘要: Abstract Human adenoviruses (AdV) cause generally mild infections of the respiratory and GI tracts as well some other tissues. However, AdV can serious infection in severely immunosuppressed individuals, especially pediatric patients undergoing allogeneic hematopoietic stem cell transplantation, where mortality rates are up to 80% with disseminated disease. Despite seriousness disease, there no drugs approved specifically treat infections. We report here that USC-087, an N-alkyl tyrosinamide phosphonate ester prodrug HPMPA, adenine analog cidofovir, is highly effective against multiple types culture. USC-087 also AdV-C6 our permissive Syrian hamster model. In this model, hamsters by treatment high dose cyclophosphamide. Injection (or AdV-C5) intravenously leads a resembles disease seen humans, including death. have tested efficacy orally-administered median lethal administered AdV-C6. completely prevented or significantly decreased when 4 days post challenge. liver damage caused infection, suppressed virus replication even These results imply promising candidate for drug development HAdV