Carcinogens induce intrachromosomal recombination in human cells

摘要: A major portion of new cases cancer may be linked to environmental carcinogens. The Ames (Salmonella) test is currently the most widely used short-term predict carcinogenic properties compounds. However, approximately 50% all carcinogens have been sufficiently tested in long-term animal bioassays do not induce mutations Salmonella assay, and many these are also detectable by other assays. In work described here we determined effect carcinogen exposure on intrachromosomal recombination a human cell line. events caused deletion one copy duplication exons 2 3 hprt gene. We found that were induced assay positive UV, gamma-rays methyl methanesulfonate, as well negative Aroclor 1221, benzene thiourea. These data further support accumulating evidence deletions important carcinogenesis.