In Vivo Treatment with Antibody against IGF-1 Receptor Suppresses Growth of Human Rhabdomyosarcoma and Down-Regulates p34cdc2
作者： Thea Kalebic , Maria Tsokos , Lee J. Helman
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摘要: In a previous study, we have shown that insulin-like growth factor type 2 (IGF-2) functions as an autocrine in human rhabdomyosarcoma (RMS) cell lines. addition, demonstrated the inhibition of binding IGF-2 to IGF-1 receptor, mediated by suramin, blocked RMS cells vitro. We now report that, vivo, specific receptor blocking antibody (alpha IR-3), but not suppresses tumor growth. Both progression tumor-bearing animals and formation newly established tumors were suppressed treatment with alpha IR-3. Histological analysis from treated did reveal necrotic lesions, implying treatments had no cytotoxic effect. The decrease was associated p34cdc2, cellular protein involved cycle regulation, suggesting resulted arrest proliferation. speculate, therefore, agents which block IGF signaling pathway may find application RMS.
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