Predictors of hemorrhage in patients with untreated brain arteriovenous malformation

摘要: Background: Intracranial hemorrhage is a serious possible complication in patients with brain arteriovenous malformation (AVM). Several morphologic factors associated hemorrhagic AVM presentation have been established, but their relevance for the risk of subsequent remains unclear. Methods: The authors analyzed follow-up data on 622 consecutive from prospective Columbia database, limited to period between initial diagnosis and start treatment (i.e., any endovascular, surgical, or radiation therapy). Univariate multivariate logistic regression Cox proportional hazard models were applied analyze effect patient age, gender, size, anatomic location, venous drainage pattern, arterial aneurysms intracranial at during follow-up. Results: mean pretreatment was 829 days (median: 102 days), which 39 (6%) experienced hemorrhage. Increasing age (hazard ratio [HR] 1.05, 95% CI 1.03 1.08), (HR 5.38, 2.64 10.96), deep location 3.25, 1.30 8.16), exclusive 1.01 5.67) independent predictors Annual rates ranged 0.9% without presentation, as high 34.4% those harboring all three factors. Conclusions: Hemorrhagic (AVM) increasing appear be natural history spontaneous may low AVMs these