Different time-course production of peptidic and nonpeptidic leukotrienes and prostaglandins E2 and F2α in the ovary during ovulation in gonadotropin-primed immature rats

摘要: Temporal changes in ovarian leukotrienes (LTs) and prostaglandins (PGs) were examined during ovulation to assess roles they may play this process. Ovulation was induced immature rats by injection with human chorionic gonadotropin (hCG; 10 IU, s.c.) 2 days after had been primed pregnant mare serum (10 s.c.). The ovaries extirpated at various intervals hCG administration assayed for LTB4, LTC4/D4/E4, as well PGE2, PGF2 alpha. Ovarian concentration of LTB4 increased (P < 0.01) rapidly, reaching a peak 1 hour administration, then declined 0.05) 4 hours remained low thereafter. In contrast, LTC4/D4/E4 peaked between hours, 0.05), achieve second, larger hours. Prostaglandin E2 6 did not decrease from the value until 14 hCG. Concentrations alpha hCG, but decreased Although all ovulation, time-course differed. This suggests that each eicosanoid distinct role process follicular rupture.