B blood group: A strong risk factor for venous thromboembolism recurrence

摘要: Abstract Background Non-O blood group patients are at higher risk of first episode venous thromboembolism (VTE). However, only little is known about the recurrence according to group. In this study, we aimed determine impact ABO on VTE recurrence. Methods We prospectively recruited 106 consecutive with a documented pulmonary embolism (PE). Patients were followed least 12 months after anticoagulation discontinuation. The main endpoint was symptomatic VTE. Results Data from 100 analyzed. Median follow-up 28 months [24–34.8]. PE unprovoked in 48 patients. Mean duration 5.3 ± 2.2 months. rate 12.7 per patient-years (30 recurrences). B had 2.7-fold increased (95%CI 1.1-6.2, p = 0.03). On multivariate analysis, strongest independent predictor (Hazard Ratio (HR) 2.6, 95%CI 1.1-6.1, p = 0.04). contrast, A and AB groups not associated recurrences less frequent O compared non-O (HR 0.5, 0.2-1.1, p = 0.09). women 5-fold decreased 0.2, 0.1-0.8, p = 0.01). Conclusions groups, beyond being involved occurrence event, also contribute strongly recurrence, thus high-risk could benefit long-term therapy event.