The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism
作者： Isabel Tirado , José Mateo , José Manuel Soria , Arturo Oliver , Elisabeth Martínez-Sánchez
DOI: 10.1160/TH04-04-0251
关键词: Medicine 、 Venous thrombosis 、 Coagulopathy 、 Thrombosis 、 Embolism 、 Internal medicine 、 Von Willebrand factor 、 ABO blood group system 、 Gastroenterology 、 Immunology 、 Case-control study 、 Thrombophilia
摘要: Factor VIII (FVIII), von Willebrand factor (vWF) and the ABO blood groups have been associated with thrombosis. The locus has functional effects on vWF FVIII levels is genetically correlated FVIII, thrombosis.We carried out a case-control study to assess role of types thrombotic risk.We analyzed 250 patients venous thrombosis unrelated controls. other factors related thrombophilia were measured, by genotyping. higher in non-O individuals. Group O was more frequent controls (44.3% v 23.3%; difference 21.1%; 95% CI:13.0-29.3%) A (59.2% v. 41.5%; 17.7%, CI:9.1-26.4%). Individuals carrying 1 allele had risk (OR 2.6; CI, 1.8-3.8).The attributed disappeared after adjusting for group. Patients above 90th percentile high (adjusted OR 3.7;95%CI,2.1-6.5), recurrence 2.3; 95%CI: 1.3-4.1). In conclusion, groups, likely those A1 allele, are independent thromboembolism should be considered evaluating thrombophilia.
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