Availability of Donor Milk for Very Preterm Infants Decreased the Risk of Necrotizing Enterocolitis without Adversely Impacting Growth or Rates of Breastfeeding.

摘要: Human milk contains non-nutritional factors that promote intestinal maturation and protect against infectious inflammatory conditions. In the Neonatal Intensive Care Unit (NICU) setting, donor (DM) is recommended when availability of own mother's (OMM) not enough. Our aim was to compare incidence necrotizing enterocolitis (NEC) late-onset sepsis (LOS) in very preterm infants (VPI) after introduction DM. Growth breastfeeding rates were examined as secondary outcomes. Single center, observational retrospective cohort study comparing 227 VPI admitted our neonatal unit before (Group 1, n = 99) 2, 128) DM introduction. Enteral nutrition started earlier (2.6 ± 1.1 vs. 2.1 1 days, p 0.001). Incidence NEC decreased group 2 (9.1% 3.4%, 0.055), especially those born between 28 32 weeks (5.4 0.0%, 0.044). Surgical also less frequent. Suffering 4 times more likely (multivariate analysis). Availability did impact or growth. findings support protective role NEC, particularly non-extreme VPI, a frequently included clinical guidelines research studies on use