Serum uric acid levels in obese children and adolescents: Linkage to testosterone levels and pre-metabolic syndrome
作者： C. Denzer , R. Muche , H. Mayer , E. Heinze , K.-M. Debatin
DOI: 10.1515/JPEM.2003.16.9.1225
关键词:
摘要: Hyperuricemia is part of the "metabolic syndrome". The aim this study was to investigate regulation and role serum uric acid in cardiovascular risk factor profile obese children adolescents. Serum levels selected factors hormones were determined 269 aged 10.0-15.9 years with a BMI >90th percentile (mean 24.0 kg/m2, SD 5.43). Stepwise regression adjusted for age sex revealed that testosterone (p < 0.0001), systolic blood pressure 0.0017), triglycerides 0.0345) cholesterol/HDL ratio 0.0393) positively correlated accounted 42.1% variance. Additional models same set variables indicated contributed significantly cholesterol/HDL, total cholesterol, pressure, respectively. These results suggest not yet described impact androgens Furthermore, they show reliable indicator "pre-metabolic syndrome" youths.
sci-hub.se 参考文章(20)
A Del Maschio, P Brambilla, G Chiumello, P Manzoni, B Di Natale, S Sironi, P Simone, Peripheral and abdominal adiposity in childhood obesity. International Journal of Obesity. ,vol. 18, pp. 795- 800 ,(1994)
Stephen R. Daniels, John A. Morrison, Dennis L. Sprecher, Philip Khoury, Thomas R. Kimball, Association of Body Fat Distribution and Cardiovascular Risk Factors in Children and Adolescents Circulation. ,vol. 99, pp. 541- 545 ,(1999) , 10.1161/01.CIR.99.4.541
Bernard Gutin, Paule Barbeau, Mark S. Litaker, Michael Ferguson, Scott Owens, Heart rate variability in obese children: relations to total body and visceral adiposity, and changes with physical training and detraining. Obesity Research. ,vol. 8, pp. 12- 19 ,(2000) , 10.1038/OBY.2000.3
S. Takahashi, T. Yamamoto, Z. Tsutsumi, Y. Moriwaki, J. Yamakita, K. Higashino, Close correlation between visceral fat accumulation and uric acid metabolism in healthy men. Metabolism-clinical and Experimental. ,vol. 46, pp. 1162- 1165 ,(1997) , 10.1016/S0026-0495(97)90210-9
M Wabitsch, H Hauner, E Heinze, A Böckmann, R Benz, H Mayer, W Teller, Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction The Journal of Clinical Endocrinology and Metabolism. ,vol. 80, pp. 3469- 3475 ,(1995) , 10.1210/JCEM.80.12.8530585
Scott Owens, Bernard Gutin, Michael Ferguson, Jerry Allison, Warren Karp, Ngoc-Anh Le, Visceral adipose tissue and cardiovascular risk factors in obese children The Journal of Pediatrics. ,vol. 133, pp. 41- 45 ,(1998) , 10.1016/S0022-3476(98)70175-1
M. Pizzichini, R. Leoncini, D. Vannoni, E. Marinello, R. Pagani, The influence of testosterone on purine nucleotide metabolism in rat liver. Life Sciences. ,vol. 57, pp. 2127- 2135 ,(1995) , 10.1016/0024-3205(95)02205-W
Enzo Bonora, Francesca Saggiani, Stefano Pilati, Giovanni Targher, Paola Branzi, Michele Muggeo, Serum uric acid and related factors in 500 hospitalized subjects. Metabolism-clinical and Experimental. ,vol. 45, pp. 1557- 1561 ,(1996) , 10.1016/S0026-0495(96)90188-2
M. A. P. S. Downham, J. McQuillin, P. S. Gardner, Diagnosis and clinical significance of parainfluenza virus infections in children Archives of Disease in Childhood. ,vol. 49, pp. 8- 15 ,(1974) , 10.1136/ADC.49.1.8
I. GYÁRFÁS, Blood pressure in childhood and adolescence. Results from an international collaborative study on juvenile hypertensiona Acta Paediatrica. ,vol. 74, pp. 11- 22 ,(1985) , 10.1111/J.1651-2227.1985.TB10079.X