The Werner syndrome protein: linking the replication checkpoint response to genome stability

摘要: The Werner syndrome protein (WRN) is a member of the human RecQ family DNA helicases implicated in maintenance genome stability. Loss WRN gives rise to syndrome, genetic disease characterised by premature aging and cancer predisposition. plays crucial role response replication stress significantly contributes recovery stalled forks, although how this function regulated not fully appreciated. There growing body evidence that accomplishes its task close connection with checkpoint. In eukaryotic cells, checkpoint response, which involves both ATR ATM kinase activities, deputed fork integrity re-establishment progression. Our recent findings indicate modulate at defined steps arrest. This review focuses on novel functional relationship between cross-talk might contribute prevent instability, common feature senescent cells.