Checking on DNA damage in S phase
作者： Jiri Bartek , Claudia Lukas , Jiri Lukas
DOI: 10.1038/NRM1493
关键词: Cell biology 、 G2-M DNA damage checkpoint 、 Checkpoint Kinase 2 、 Genome 、 Gene 、 CHEK1 、 Ataxia Telangiectasia Mutated Proteins 、 DNA damage 、 Cell Cycle Protein 、 Biology 、 Neuroscience
摘要: The precise replication of the genome and continuous surveillance its integrity are essential for survival avoidance various diseases. Cells respond to DNA damage by activating a complex network so-called checkpoint pathways delay their cell-cycle progression repair defects. In this review we integrate findings on emerging mechanisms activation, signalling spatio-temporal organization intra-S-phase DNA-damage impact machinery, discuss biological significance.
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sci-hub.se 参考文章(113)
Jacob Falck, Niels Mailand, Randi G. Syljuåsen, Jiri Bartek, Jiri Lukas, The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. ,vol. 410, pp. 842- 847 ,(2001) , 10.1038/35071124
Jirina Bartkova, Niels Mailand, Lucia Latella, Jiri Lukas, Jiri Bartek, Tine Schroeder, Claudia Lukas, Jacob Falck, Maxwell Sehested, DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Research. ,vol. 61, pp. 4990- 4993 ,(2001)
Yosef Shiloh, Michael B. Kastan, ATM: Genome stability, neuronal development, and cancer cross paths Advances in Cancer Research. ,vol. 83, pp. 209- 254 ,(2001) , 10.1016/S0065-230X(01)83007-4
Tamara A. Mochan, Thanos D. Halazonetis, Richard A. DiTullio, Monica Venere, 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Research. ,vol. 63, pp. 8586- 8591 ,(2003)
Bin-Bing S. Zhou, Stephen J. Elledge, The DNA damage response: putting checkpoints in perspective Nature. ,vol. 408, pp. 433- 439 ,(2000) , 10.1038/35044005
Edward T Kipreos, Michele Pagano, The F-box protein family. Genome Biology. ,vol. 1, pp. 1- 7 ,(2000) , 10.1186/GB-2000-1-5-REVIEWS3002
Kyungjae Myung, Clark Chen, Richard D. Kolodner, Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae Nature. ,vol. 411, pp. 1073- 1076 ,(2001) , 10.1038/35082608
Hiroyuki Takai, Kaoru Tominaga, Noboru Motoyama, Yohji A Minamishima, Hiroyasu Nagahama, Tadasuke Tsukiyama, Kyoji Ikeda, Keiko Nakayama, Makoto Nakanishi, Kei-ichi Nakayama, None, Aberrant cell cycle checkpoint function and early embryonic death in Chk1 −/− mice Genes & Development. ,vol. 14, pp. 1439- 1447 ,(2000) , 10.1101/GAD.14.12.1439
Pedro Jares, Anne Donaldson, J Julian Blow, The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? EMBO Reports. ,vol. 1, pp. 319- 322 ,(2000) , 10.1093/EMBO-REPORTS/KVD076
Mark O'Driscoll, Victor L. Ruiz-Perez, C. Geoffrey Woods, Penny A. Jeggo, Judith A. Goodship, A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome Nature Genetics. ,vol. 33, pp. 497- 501 ,(2003) , 10.1038/NG1129