The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma
作者： Laura W. Dillon , Christine E. Lehman , Yuh-Hwa Wang
DOI: 10.1155/2012/927683
关键词:
摘要: The incidence of thyroid cancer is increasing, especially papillary carcinoma (PTC), making it currently the fastest-growing among women. Reasons for this increase remain unclear, but several risk factors including radiation exposure and improved detection techniques have been suggested. Recently, induction chromosomal fragile site breakage was found to result in formation RET/PTC1 rearrangements, a common cause PTC. Chromosomal sites are regions genome with high susceptibility forming DNA breaks often associated cancer. Exposure variety external agents can induce breakage, which may account some observed This paper discusses role PTC development, site-inducing that be potential PTC, how these targeting
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