Effect of sterilization on bone morphogenetic protein.
作者： Shinichiro Ijiri , Takao Yamamuro , Takashi Nakamura , Seiya Kotani , Kouchei Notoya
关键词:
摘要: Demineralized bone matrix and morphogenetic protein have been used clinically to accelerate regeneration. However, the best method of sterilization has subject controversy. Some investigators ethylene oxide, but others reported that doses adequate for destroyed osteoinductivity demineralized gamma irradiation was less harmful in this respect. We partially purified type-I collagen investigate effects by oxide on activity protein. Osteoinductivity reduced considerably after at 2.5 Mrad 37 degrees C 4 hours 55 1 hour; however, reduction induced 29 5 about half control values. This study showed can be also investigated effect carrier separately found far more labile than
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