Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study.

摘要: Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm with a variable histologic appearance that may mimic other spindle cell processes, particularly nodular fasciitis, desmoid tumor, and in intra-abdominal locations, gastrointestinal stromal tumor. Recently, gene fusions involving ALK at chromosome 2p23 have been described IMTs. The resultant protein overexpression the component of these tumors detectable by immunohistochemistry. We examined 73 IMTs, 20 cases 15 fibromatoses, immunohistochemistry using ALK-11, rabbit polyclonal antibody recognizes C-terminus protein. positivity was detected 44 (60%) All fibromatosis, were negative (p < 0.001). These findings demonstrate common anti-ALK antibodies can be helpful differential diagnosis neoplasms. In addition, staining seems to correlate those IMTs typical tri-patterned clinical presentation, providing additional support premise IMT distinctive clinicopathologic entity within broad category inflammatory pseudotumors.