Chd2 interacts with H3.3 to determine myogenic cell fate
作者： Akihito Harada , Seiji Okada , Daijiro Konno , Jun Odawara , Tomohiko Yoshimi
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摘要: Cell differentiation is mediated by lineage-determining transcription factors. We show that chromodomain helicase DNA-binding domain 2 (Chd2), a SNF2 chromatin remodelling enzyme family member, interacts with MyoD and myogenic gene regulatory sequences to specifically mark these loci via deposition of the histone variant H3.3 prior cell differentiation. Directed genome-wide analysis endogenous incorporation demonstrates knockdown Chd2 prevents at differentiation-dependent, but not housekeeping, genes inhibits activation. The data indicate determines fate facilitates differentiation-dependent expression through Chd2-dependent
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Aviad Keren, Yael Tamir, Eyal Bengal, The p38 MAPK signaling pathway: A major regulator of skeletal muscle development Molecular and Cellular Endocrinology. ,vol. 252, pp. 224- 230 ,(2006) , 10.1016/J.MCE.2006.03.017
Concetta G.A. Marfella, Yasuyuki Ohkawa, Andrew H. Coles, David S. Garlick, Stephen N. Jones, Anthony N. Imbalzano, Mutation of the SNF2 family member Chd2 affects mouse development and survival Journal of Cellular Physiology. ,vol. 209, pp. 162- 171 ,(2006) , 10.1002/JCP.20718
Saori Yoshimura, Akihito Harada, Jun Odawara, Masayuki Azuma, Seiji Okada, Mako Nakamura, Yasuyuki Ohkawa, Taro Tachibana, Rat Monoclonal Antibody Specific for the Chromatin Remodeling Factor, CHD1 Hybridoma. ,vol. 29, pp. 237- 240 ,(2010) , 10.1089/HYB.2009.0106
Nanako Takizawa, Naohito Nozaki, Hiroshi Kimura, Yoko Hayashi-Takanaka, Yuji Goto, The Organization of Histone H3 Modifications as Revealed by a Panel of Specific Monoclonal Antibodies Cell Structure and Function. ,vol. 33, pp. 61- 73 ,(2008) , 10.1247/CSF.07035
Yumiko Kishiro, Megumi Kagawa, Ichiro Naito, Yoshikazu Sado, A novel method of preparing rat-monoclonal antibody-producing hybridomas by using rat medial iliac lymph node cells Cell Structure and Function. ,vol. 20, pp. 151- 156 ,(1995) , 10.1247/CSF.20.151
Masaki Okano, Daphne W Bell, Daniel A Haber, En Li, DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. ,vol. 99, pp. 247- 257 ,(1999) , 10.1016/S0092-8674(00)81656-6
Marilyn G. Pray-Grant, Jeremy A. Daniel, David Schieltz, John R. Yates, Patrick A. Grant, Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation Nature. ,vol. 433, pp. 434- 438 ,(2005) , 10.1038/NATURE03242
I M Berenjeno, F Núñez, X R Bustelo, Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases Oncogene. ,vol. 26, pp. 4295- 4305 ,(2007) , 10.1038/SJ.ONC.1210194
Alexandre Gaspar-Maia, Adi Alajem, Fanny Polesso, Rupa Sridharan, Mike J. Mason, Amy Heidersbach, João Ramalho-Santos, Michael T. McManus, Kathrin Plath, Eran Meshorer, Miguel Ramalho-Santos, Chd1 regulates open chromatin and pluripotency of embryonic stem cells Nature. ,vol. 460, pp. 863- 868 ,(2009) , 10.1038/NATURE08212
P Nagarajan, T M Onami, S Rajagopalan, S Kania, R Donnell, S Venkatachalam, Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene. ,vol. 28, pp. 1053- 1062 ,(2009) , 10.1038/ONC.2008.440