Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders.
作者： Madhulika Pradhan , Deependra Singh , Manju Rawat Singh
DOI: 10.3109/21691401.2014.955105
关键词:
摘要: Aim of the study was to develop solid lipid nanoparticles (SLN) triamcinolone acetonide (TA) and effect various process variables in order optimize formulation for effective delivery. Drug loaded SLNs were successfully prepared characterized by TEM, XRD DSC study. Process like surfactant concentration, drug concentration etc. showed significant on particle size entrapment efficiency. exhibited prolonged release following Higuchi kinetics (R2 = 0.9909). In vitro skin distribution demonstrated systemic escape from TA which might eliminate side effects associated with exposure.
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