Ceramic nanocarriers: versatile nanosystem for protein and peptide delivery.

作者: Deependra Singh , Pooja Dubey , Madhulika Pradhan , Manju Rawat Singh

DOI: 10.1517/17425247.2012.745848

关键词:

摘要: Introduction: Proteins and peptides have been established to be the potential drug candidate for various human diseases. But, delivery of these therapeutic protein is still a challenge due their several unfavorable properties. Nanotechnology expanding as promising tool efficient proteins peptides. Among numerous nano-based carriers, ceramic nanoparticles proven themselves unique carrier peptide they provide more stable, bioavailable, readily manufacturable, acceptable polypeptide formulation. Areas covered: This article provides an overview aspects including classification, methods preparation, latest advances, applications carriers. Expert opinion: Ceramic nanocarriers seem preserving structural integrity peptides, thereby promoting better effect. approach thus pro...

参考文章(94)
Richard E Riman, Wojciech L Suchanek, Malgorzata M Lencka, None, Hydrothermal crystallization of ceramics Annales De Chimie-science Des Materiaux. ,vol. 27, pp. 15- 36 ,(2002) , 10.1016/S0151-9107(02)90012-7
Meryem Özmak, Neşe Burcu Savak, Yuda Yürüm, Ahu Gümrah Dumanlı, Abdülkerim Karabakan, Murat Akgül, Adsorption of bovine serum albumin (BSA) on clinoptilolite Hacettepe Journal of Biology and Chemistry. ,vol. 36, pp. 21- 29 ,(2008)
P. Q. Ruhé, O. C. Boerman, F. G. M. Russel, A. G. Mikos, P. H. M. Spauwen, J. A. Jansen, In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin. Journal of Materials Science: Materials in Medicine. ,vol. 17, pp. 919- 927 ,(2006) , 10.1007/S10856-006-0181-Z
Huinan Liu, Thomas J Webster, Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications. International Journal of Nanomedicine. ,vol. 5, pp. 299- 313 ,(2010) , 10.2147/IJN.S9882
Krasimir Vasilev, Zihan Poh, Krishna Kant, Joseph Chan, Andrew Michelmore, Dusan Losic, Tailoring the surface functionalities of titania nanotube arrays Biomaterials. ,vol. 31, pp. 532- 540 ,(2010) , 10.1016/J.BIOMATERIALS.2009.09.074
Vladimir P. Torchilin, Anatoly N. Lukyanov, Peptide and protein drug delivery to and into tumors: challenges and solutions. Drug Discovery Today. ,vol. 8, pp. 259- 266 ,(2003) , 10.1016/S1359-6446(03)02623-0
KATSUHIDE YUTANI, KYOKO OGASAHARA, YOSHINOBU SUGINO, AIZO MATSUSHIRO, Effect of a single amino acid substitution on stability of conformation of a protein. Nature. ,vol. 267, pp. 274- 275 ,(1977) , 10.1038/267274A0
Majid Zeinali, Mostafa Jammalan, Sussan K. Ardestani, Nader Mosaveri, Immunological and cytotoxicological characterization of tuberculin purified protein derivative (PPD) conjugated to single-walled carbon nanotubes. Immunology Letters. ,vol. 126, pp. 48- 53 ,(2009) , 10.1016/J.IMLET.2009.07.012
Hubert F. Gaertner, Fabrice Cerini, Arun Kamath, Anne-Françoise Rochat, Claire-Anne Siegrist, Laure Menin, Oliver Hartley, Efficient orthogonal bioconjugation of dendrimers for synthesis of bioactive nanoparticles. Bioconjugate Chemistry. ,vol. 22, pp. 1103- 1114 ,(2011) , 10.1021/BC1005653