Effects of non-ionic monomeric and dimeric iodinated contrast media on renal and systemic haemodynamics in rats.

摘要: — Non-ionic dimeric contrast media (CM) are a new class of CM which iso-osmolar with plasma. The aim this study was to investigate their effects on systemic and renal haemodynamics. non-ionic iodixanol the monomeric agent iobitridol (both at dose 1600 mgl/kg) were compared in terms blood pressure (BP) flow (RBF) two strains rats (Wistar Sprague Dawley). Iodixanol significantly lowered BP Wistar (− 33 ± 9% baseline, 10 min post-injection, P < 0.001 vs. saline iobitridol). Iobitridol had virtually no effect BP. decreased RBF. This more marked following injection dimer rather than monomer (iodixanol: − 32 13%, iobitridol: 20 4% baseline 16 min, 0.05). For both agents, RBF still 50 30 11% 5% baseline). also Dawley rats, while remained unchanged. suggests that changes BP/RBF autoregulation do not account for haemodynamic agent. When measured 2 h injection, iodixanol-induced hypoperfusion detectable 29% saline-treated rats), although significant (P = 0.06). longer observed 4 injection. Increasing infusion rate (18 mL/h mL/h) during experiment did decrease rats. In spite its iso-osmolality, iodixanol, CM. depressed iobitridol, agent, long-lasting alleviated by increasing hydration rate.