11 Mechanisms of dengue virus-induced bone marrow suppression

摘要: Infection with many flaviviruses is associated transient suppression of haematopoiesis. Of the man, none are more accessible to clinical and laboratory study than dengue. Consequently, syndrome dengue-associated bone marrow has been well documented. A review experimental dengue infections volunteers histopathological studies from patients severe virus infection suggests that evolves rapidly through several phases: (1) onset within 3-4 days infection; (2) host inflammatory responses in fever shortly thereafter; (3) occurrence a neutrophil nadir on fourth fifth day after fever; (4) almost simultaneously, immune activation sufficient neutralize viraemia accelerate elimination infected cells; (5) remission symptoms; (6) resolution cytopenias. Clinical observations data bear possible mechanisms virus-mediated suppression. Work authors' which long-term cultures were used investigate interactions between cells (stromal elements haematopoietic progenitors) also reviewed. Long-term culture (LTMC) was useful system. In vitro, early blast as differentiated abortively infected, killed eliminated by phagocytosis specialized macrophages called dendritic cells. Moreover, ARC stroma rather precursors productively infected. When failed support Cytokine production virus-infected stromal altered. hypothesis proposed account for virus-induced Down-regulation haematopoiesis probably protective mechanism microenvironment limits injury stem/progenitor cell compartment during subsequent process