Nerve vasculature changes induced by serotonin under chronic cauda equina compression.

摘要: STUDY DESIGN An analysis of nerve vascular changes in roots induced by serotonin chronically compressed roots. OBJECTIVES To assess the hypotheses that might have a vasoconstrictive effect SUMMARY OF BACKGROUND DATA The 5-hydroxytryptamine 2A receptor is involved serotonin-induced activation or sensitization sensory terminals. Serotonin exerts complex effects on pain and hyperalgesia through various subtypes located at levels transmission system. induces endothelium-dependent contraction diseases. However, there no knowledge regarding response vasculature METHODS A total 45 dogs were used. plastic balloon was placed under lamina L7 inflated to 10 mm Hg left for 1 week. Four experimental groups used: operation (Group A, n = 15), but not B, 10), week pressure released just before measurement C, inflation maintained during measurements D, 10). blood vessels second third sacral defined after an intra-arterial injection 0.5 micromol/L 1.0 using specially designed microscope equipped with video camera. In all (each group, 5) injected. Group (n saline diameter observed flow index performed recordings. All statistical assessments Wilcoxon signed-ranks test Fisher's PLSD. RESULTS did change administration saline. noncompression (Groups B) increased serotonin. compression C D) contracted injecting decreased. There significant difference between (P < 0.01). C) group D). decreased micromol/L. electron microscopic observation tight junction endothelial cells destroyed DISCUSSION present study demonstrated had vasodilative intact roots, whereas group. Results suggested dysfunction rather than mechanical itself lead chronic compression. CONCLUSION