The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.

摘要: Survival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk late effects therapy. Endocrine problems very common in these patients. The recognition and prompt management essential to prevent further morbidity impairment quality life. Cranial radiation can damage hypothalamic–pituitary function, most frequently affecting GH status; however, higher doses may cause more widespread damage. Early puberty secondary cranial irradiation now being managed with gonadotrophin-releasing hormone analogues improve final height. Prompt diagnosis deficiency height outcome; continued beyond aids the achievement adult body composition (lean mass bone mass) adulthood improves Both alone spinal result thyroid resulting hypothyroidism nodules, high proportion which malignant. Gonadal adjuvant chemotherapy have long-term consequences including infertility.