Arabinogalactan-coated superparamagnetic iron oxide: effect of particle size in liver MRI.

摘要: OBJECTIVE We evaluated the effect of particle size on MR contrast-enhancing properties arabinogalactan-coated superparamagnetic iron oxide (AG-SPIO) in tumor-bearing rats. MATERIALS AND METHODS T2*-weighted gradient-recalled echo studies were performed rats with surgically implanted liver tumors before and after AG-SPIO administration. Contrast-to-noise ratio (CNR) percent contrast enhancement (PCE) calculated for animals given small (15.7 +/- 9.5 nm: n = 6), medium (49.1 19.7 nm; 4), large (86.9 27.5 4) particles intravenously (10 mumol Fe/kg). RESULTS Postcontrast CNRs 15.8 6.9, 8.9 4.1, 10.0 1.8 small, medium, groups, respectively. The PCE was -60.0 3.3, -75.5 7.9, -80.5 1.2%. There a significant difference preversus postcontrast CNR all sizes (p < 0.001) as compared two larger 0.001). no between-group statistical any size. CONCLUSION Larger slightly improve enhancement, but have hepatic lesion detection assessed by CNR.