A developmental transition in growth control during zebrafish caudal fin development.

摘要: A long-standing question in developmental biology is how do growing and developing animals achieve form then maintain it. We have revealed a critical transition growth control during zebrafish caudal fin development, wherein switch from allometric to isometric occurs. This morphological led us hypothesize additional physiological changes pathways. To test this, we fasted juvenile adult zebrafish. Juvenile fins continued until development of the mature bi-lobed shape was completed. In contrast, arrested within days initiating fast. explored biochemical basis this difference physiology between two phases by assessing sensitivity rapamycin, drug that blocks nutrient-sensing pathway. show nutrition-independent, phase resistant rapamycin at 10-fold higher concentrations than are effective arresting nutrition-dependent, phase. thus link mechanisms different responses nutritional state animal finally pharmacological (rapamycin) affects nutrition-sensing mechanism described yeast human.