Intercellular adhesion molecule-1 mediates the expression of monocyte-derived MIP-1 alpha during monocyte-endothelial cell interactions.

摘要: production of MIP-1 a, a mononuclear cell Chemotactic protein, during monocyte:endothelial interactions. Neither unstimulated nor interferon (IFN)-stimulated human umbilical vein endothelial cells (HUVECs) produced substantial MIP-la protein. However, the addition enriched monocyte populations with HUVECs resulted in MIP-la. Monocytes cultured IFN-7activated showed an additional increase MIP1 production. Immunohistochemical analysis demonstrated that was cellular source this coculture system. The mechanism HE EVOLUTION inflammatory response is known to involve intimate relationship between adhesion molecules and chemokines results localization, extravasation, recruitment leukocytes site inflammation. vascular interaction activated blood near initially dependent on cytokine-induced, cell-derived molecules."' Presently concept adhered must be drawn into tissue through series detachmentlreadherence events typified by polar expression integrins specific for surface mesenchymalderived cek3 movement thought mediated concentration gradients appear chemotactic groups leukocytes. Recent studies have identified C-C family as important monocyte/lymphocyte fact01-s.~ Adhesion shown p, member chemokine family, binding CD44 association VCAM-1 mole