Determination of the amino acid sequence in a cyclic lipopeptide using MS with DHT mechanism.
作者： Shi-Zhong Yang , Dong-Zhi Wei , Bo-Zhong Mu
DOI: 10.1016/J.JBBM.2006.03.008
关键词:
摘要: A TOF MS/MS method to directly determine the amino acid sequence in a cyclic lipopeptide without its hydrolysis is described. The fragments of peptide and hydrocarbon chains were identified through comparing MS two analogues lipopeptide; connecting relationship residues was determined based on difference mass charge ratio between peaks spectra analysis; finally, according mechanism double hydrogen transfer(DHT) C-terminal hydroxy aliphatic hydrolysis. also supported by rest grounded simple fragmenting mechanism. This can be used any loop-inlaying lipopeptides.
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