Degradation of cefquinome in spiked milk as a model for bioremediation of dairy farm waste milk containing cephalosporin residues

摘要: AIMS The aims of this work were to develop a model dairy farm waste milk and investigate methods for the bioremediation containing cefquinome residues. METHODS AND RESULTS Unpasteurized UHT that had both been spiked with at concentration 2 μg ml(-1) used as cephalosporin Adjustment pH 10 or treatment conditioned medium from bacterial growth producing cefotaximase, most effective decreasing concentrations within 24 h. A large-scale experiment (10 l cefquinome-spiked unpasteurized milk) suggested fermentation 22 h 37°C followed by heating 60°C was sufficient decrease below limit quantification (<125 kg(-1) ) kill majority enriched population. CONCLUSIONS One combination described may have potential practical milk. SIGNIFICANCE IMPACT OF THE STUDY Treatment residue also bacteria prior feeding calves could risk selection ESBL on farms.