Macroglobulinemia: An Analysis for Forty Patients

摘要: Forty patients with Waldenstrom’s macroglobulinemia were evaluated for criteria of diagnosis, clinical presentation and course, response to therapy, appropriateness the classification primary or secondary. A wide spectrum presentations, complications present. Thus, major diagnosis was a monoclonal IgM serum protein abnormality present in concentrations greater than 1 g/100 ml. Clinical manifestations included weight loss, mucous membrane bleeding, presence abnormal masses, lymphadenopathy, hepatosplenomegaly, peripheral neuropathy, central nervous system abnormalities. high incidence (60%) associated malignancy noted. The hyperviscosity syndrome frequent complication (33%). Alkylating drugs successful inducing remission approximately 40% patients. Plasmapheresis uniformly relieving hyperviscosity. It found that attempts classify as secondary frequently proved error long-term observation such should be discarded. Hypotheses etiology are discussed include proteins as: markers malignant lymphoid line, antibodies microscopic submicroscopic organisms related (or not related) tumor induction, tumor-specific antigens. Firm evidence any these possibilities is available.