Laser ablation sampling of materials directly into the formed liquid microjunction of a continuous flow surface sampling probe/electrospray ionization emitter for mass spectral analysis and imaging.

摘要: Transmission geometry laser ablation directly into a formed liquid microjunction of continuous flow surface sampling probe/electrospray ionization emitter was utilized for molecular and elemental detection mass spectrometry imaging. The ability to efficiently capture ionize ablated material demonstrated by the various small soluble n-mers polyaniline silver ion solvent clusters from electropolymerized thin films, respectively. In addition, analysis surfaces that contain components accomplished coating or laminating sample with an insoluble film enable junction formation without extracting surface. perform imaging at spatial resolution about 50 μm illustrated using laminated inked patterns on microscope slide. general, these data demonstrate least order magnitude signal enhancement compared noncontact, droplet capture-based sampling/ionization approaches have been previously presented.