What is the mechanism of action of anti-tumour necrosis factor-alpha antibody in rheumatoid arthritis?

摘要: The rationale for anti-tumour necrosis factor-alpha (anti-TNFalpha) therapy in rheumatoid arthritis (RA) is based on experiments cultures of human rheumatoidjoint tissue, supported by animal models, all which demonstrated that anti-TNFalpha antibody had profound effects the disease activity. Clinical trials have substantiated this concept, and we used serum samples from clinical trials, as well biopsies to study changes occurring during clues pathogenesis RA. major are downregulating cytokine activity, reducing leucocyte trafficking joints.