Assessment of clinical manifestations, disease activity and organ damage in 996 Korean patients with systemic lupus erythematosus: comparison with other Asian populations.
作者： Young Bin Joo , Sang Cheol Bae
关键词:
摘要: Aim To describe the clinical manifestations, disease activity and organ damage in Korean patients with systemic lupus erythematosus (SLE). Method American College of Rheumatology (ACR) criteria, SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/ACR index (SDI) were assessed from 1998 to 2012. Results A total 996 analyzed. The common accrual ACR criteria included: immunologic (93%), hematologic arthritic (66%) nephritic (50%). In inception cohort over 10 years follow-up (n = 120), number increased significantly (5.0 ± 1.2 5.7 ± 1.3), nephritis, serositis neuropsychiatric symptoms tended increase continuously time. SLEDAI-2K decreased (5.6 ± 3.4 4.1 ± 1.2), but percentage SLEDAI scores ≥ 12 did not decrease damages musculoskeletal (14.9%) renal (11.1%). mean SDI score (0.4 ± 0.8 1.1 ± 1.6) had two peaks 1 6–10 years, predominant 5 years, ophthalmic sharply 10 years. Conclusion Compared other Asian cohorts, was lower less our cohort. Nephritis, Overall significantly, a small portion severe continued during course. most musculoskeletal. time development varied, which reflects possible causality, such as itself and/or treatment.
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