MDR1 gene polymorphism: therapeutic response to paroxetine among patients with major depression.
作者： Alma Mihaljevic Peles , Nada Bozina , Marina Sagud , Martina Rojnic Kuzman , Mila Lovric
DOI: 10.1016/J.PNPBP.2008.03.018
关键词:
摘要: Abstract The multidrug resistance transporter, P-glycoprotein (P-gp), encoded by polymorphic MDR1 (ABCB1) gene, is involved in efflux transport of several antidepressants and acts as a barrier to different exogenous noxa the blood-brain barrier. gene belongs best understood mediators drug resistance. Different polymorphisms have been found be connected with P-gp expression function. aims study were investigate potential influence polymorphisms, exon 26 C3435T 21 G2677T/A, on treatment response paroxetine (20 mg/day) patients major depression. To assess evaluate therapeutic paroxetine, all rated weekly using HAMD-17 scale. Responders defined subjects decrease HAMD scale ≥ 50% at week 6 treatment. population included 127 depression (diagnosed Structured Clinical Interview for DSM-IV disorders). Our results indicated that variants G2677T are not associated depressive disorder. associations between still need clarified.
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