Inhibition of proliferation of MIs- and Ia-reactive cloned T cells by a monoclonal antibody against a determinant shared by I-A and I-E.

摘要: The interaction between cloned amplifier T cells and stimulating has been probed with the use of a monoclonal antibody selected for its ability to inhibit stimulation Mls- la-reactive cells. recognizes public determinant on I-A- I-E-coded molecules variety murine H-2 haplotypes. inhibits proliferation I-Ab-reactive cell clone 48.1 Mls-reactive clones L2 Fa 13. may be added as late 3 hr after initiation culture cause inhibition release interleukin 2. A profound primary secondary mixed leukocyte responses also is observed. results indicate that large fraction Mls reactive require la antigens.