Unidirectional responses to Mls determinants in vivo. Polyclonal T-cell responses to a single common determinant of Mls in different efficiencies?

摘要: Polyclonal anti-Mls responses of peripheral (mature) and thymic (immature) lymphocytes were studied in vivo terms local host-versus-graft graft-versus-host reactions. The level stimulatory activity differed between the various types Mls antigens, with Mlsa Mlsd having highest levels, Mlsc a lower level, Mlsb lowest level. immunogenicity may not be identical, since mice responded to determinant, while did react determinants. This suggests that response is unidirectional. fact made tolerant at birth (Mlsa) antigens behave like when responding supports this suggestion. Furthermore, thymus cells from Mlsa-tolerized BALB/c (Mlsb) unresponsive both those responsive Mlsa. These results indicate polyclonal strongly immunogenic Mlsad unidirectional, identical. Based on tolerance experiments data T-cell clones, we suggest difference b. d due different efficiencies populations, probably because quantitative single common antigenic determinant expressed each haplotype, which levels stimulation T according avidity for determinant.