Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer

摘要: Purpose Bisphosphonates have been shown to inhibit and deplete macrophages. The effects of bisphosphonates on other cell types in the tumor microenvironment insufficiently studied. Here, we sought determine ovarian cancer angiogenesis growth via their effect microenvironment, including macrophage, endothelial populations. Experimental Design Using vitro vivo models, examined clodronate macrophage density, overall size metastasis. Results Clodronate inhibited secretion pro-angiogenic cytokines by cells macrophages, decreased migration capillary tube formation. In treated mice, significantly size, number nodules, tumor-associated macrophages density. Conclusions Clodronate is a potent inhibitor angiogenesis. These results highlight as potential therapeutic for cancer.