Endogenous hormones and risk of breast cancer in postmenopausal women

摘要: Multiple lines of evidence support a central role hormones in the etiology breast cancer. In epidemiologic studies, considerable effort has focused on delineating endogenous risk cancer among postmenopausal women. Recently, substantial additional data accrued from prospective studies where are measured study subjects prior to disease diagnosis. this review, linking sex steroids, prolactin and insulin-like growth factors (IGF) with subsequent women is summarized evaluated. Overall, strong positive association between circulating levels both estrogens androgens now been well confirmed; hormone top 20% distribution (versus bottom 20%) have 2- 3-fold higher Accumulating also indicate significant levels, although confirmation needed. contrast, no important link found IGF-I (and its binding protein, IGFBP-3)