Characterization of Left Atrial Mechanics in Hypertrophic Cardiomyopathy and Essential Hypertension Using Vector Velocity Imaging

摘要: Background Systemic hypertension (HTN) and hypertrophic cardiomyopathy (HCM) may be associated with left atrial (LA) dilation, but whether LA functional abnormalities are characteristic to each disease or not, is unknown. The aim of this study was characterize mechanical changes in patients HTN HCM using vector velocity imaging (VVI). Methods VVI-derived longitudinal function acquired from apical views 76 CM patients, 33 30 age-matched controls. Peak strain (ɛsys), rate during systole (SRsys), early diastole (SRe), late (SRa) were measured (corresponding reservoir, conduit contractile functions, respectively). Similar parameters used assess ventricular (LV) function. Results LV mass volume index higher than Both Reservoir (LA ɛsys SRsys) (SRe) more declined comparison controls (P < 0.0001),whereas the only deteriorated group. preserved among patient groups. In HCM, LV SRa [P < 0.001] independent predictors for ɛsys. While hypertension, LVMI an predictor dysfunction (P < 0.01). By receiver operating analyses, reservoir extrapolative appeared accurate discriminating both controls, ɛsys ≤ 33% being sensitive (71.8%) specific (75%). Conclusions Response mechanics pathologic hypertrophy entirely different. functions related severity phenotype, while chiefly affected linked a advanced disease.