Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde.
作者： Deepa Sinha , Anjani K. Tiwari , Sweta Singh , Gauri Shukla , Pushpa Mishra
DOI: 10.1016/J.EJMECH.2007.03.022
关键词:
摘要: Eight novel heterocyclic Schiff bases derived from the condensation reactions of indole 3-carboxaldehyde with different l-amino acids (histidine, glutamic acid, aspartic leucine, valine) as well some aminophenols, have been synthesized and characterized by various spectroscopic methods (IR, MS, (1)H NMR). base derivatives were labeled (99m)Tc radiochemical purity was above 97% which is ascertained instant thin layer chromatography using solvent conditions. Stability studies all determined under physiological conditions stable for more than 24h. Blood clearance showed a quick wash out circulation biological half life found to be t((1/2))(F)=1h 15min; t((1/2))(S)=10h 05min. Excellent quality radioimages tumor bearing mice recorded showing rapid background activity, visualization at 3h kidneys histidine analogue further evidenced in biodistribution studies. Antimicrobial activity these compounds evaluated against Bacillus subtilis, Pseudomonas fluorescence, Staphylococcus aureus, Aspergillus niger, Candida albicans Trichophyton rubrum.
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