Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas.

摘要: In the exocrine organs, breast and pancreas, colloid carcinoma (CC, pure mucinous carcinoma), characterized by well-circumscribed lakes of mucin that contain scanty, detached malignant cells, has a significantly better prognosis than conventional ductal carcinomas (DCs). It been speculated us others an inverse polarization cells may be responsible for accumulation extracellular mucin. Another possibility is this biochemically biologically distinct from secreted these organs. This study was undertaken to investigate two hypotheses: 1) To test whether there indeed alteration in cell polarity CC. Immunohistochemical stains luminal surface glycoproteins (carcinoembryonic antigen pancreas MUC1 breast) were performed 18 pancreatic 30 mammary CCs compared with expression pattern DCs (37 47 mammary) normal ducts. The results disclosed expressed predominantly stroma-facing surfaces CC contrast DCs, which either on (in well-differentiated areas) or dispersed throughout cell, intracytoplasmic poorly differentiated areas. Ultrastructural examination 10 showed condensation mucigen granules (generally underlying apical-type membrane) all cases. contrast, (five five mammary), no clustering identified cytoplasm facing stroma any Furthermore, external lamina basement membrane detected CCs, whereas 3 10) discontinuous (4 separated tumor stroma. 2) determine frequency MUC2 compare it tissue, immunohistochemical (clone ccp58) performed. exceedingly rare (1 136 DC mammary, p <0.0001 both organs). No labeling conclusion, appears coupling factors important distinctive morphologic characteristics slow growth CCs: first one orientation as evidenced direction secretory organelles disruption cell-stroma interaction manifested lack basal formation. Apparently, altered allows secrete toward produced, (also called gel-forming mucin), highly specific known form strong bonds stroma, also found recently have suppressor activity. mucin, accumulated surrounding act containing factor, slackening spread cells.