MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas
作者： SUGURU YONEZAWA , MICHIKO TAIRA , MASAHIKO OSAKO , MASAAKI KUBO , SADAO TANAKA
DOI: 10.1111/J.1440-1827.1998.TB03913.X
关键词:
摘要: The expression of MUC-1 mucin (membrane-associated mucin) and MUC-2 (secretory were immunohistochemically examined in 46 invasive ductal carcinomas (IDC) 16 intraductal papillary mucinous tumors (IPMT) the pancreas. Intraductal usually reveal expansive growth. However, IPMT present study, three showed an growth pattern, which was similar to 'mucinous carcinoma', around non-invasive areas. Of IDC, detected by monoclonal antibodies, DF3 MY.1E12, expressed 44 cases (96%) 45 (98%), respectively, whereas polyclonal antibody, anti-MRP, not any (0%). In contrast, areas IPMT, MY.1E12 four (25%) six (38%), anti-MRP 13 (81%). positive mucins although negative mucins, except for their focal one cases. These findings indicate that acquire a characteristic is seen IDC.
sci-hub.se 参考文章(15)
J R Gum, J C Byrd, J W Hicks, N W Toribara, D T A Lamport, Y S Kim, Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. Journal of Biological Chemistry. ,vol. 264, pp. 6480- 6487 ,(1989) , 10.1016/S0021-9258(18)83373-7
Miyako Abe, Donald Kufe, None, Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 282- 286 ,(1993) , 10.1073/PNAS.90.1.282
Yukie Tashiro, Suguru Yonezawa, Young S. Kim, Ellchi Sato, Immunohistochemical study of mucin carbohydrates and core proteins in human ovarian tumors Human Pathology. ,vol. 25, pp. 364- 372 ,(1994) , 10.1016/0046-8177(94)90144-9
Masahiko Osako, Suguru Yonezawa, Bader Siddiki, Jian Huang, Jenny J. L. Ho, Young S. Kim, Eiichi Sato, Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer. ,vol. 71, pp. 2191- 2199 ,(1993) , 10.1002/1097-0142(19930401)71:7<2191::AID-CNCR2820710705>3.0.CO;2-X
Donald Kufe, Giorgio Inghirami, Miyako Abe, DANIEL HAYES, HELEN JUSTI-WHEELER, JEFFREY SCHLOM, None, Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma. ,vol. 3, pp. 223- 232 ,(1984) , 10.1089/HYB.1984.3.223
Kaneteru Yamashita, Suguru Yonezawa, Sadao Tanaka, Hiroshi Shirahama, Koro Sakoda, Kohzoh Imai, Pei-Xiang Xing, Ian F. C. McKenzie, John Hilkens, Young S. Kim, Eiichi Sato, Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. International Journal of Cancer. ,vol. 55, pp. 82- 91 ,(1993) , 10.1002/IJC.2910550116
Masaya Yamamoto, V. P. Bhavanandan, Shoji Nakamori, Tatsuro Irimura, A novel monoclonal antibody specific for sialylated MUC1 mucin Japanese Journal of Cancer Research. ,vol. 87, pp. 488- 496 ,(1996) , 10.1111/J.1349-7006.1996.TB00250.X
J Siddiqui, M Abe, D Hayes, E Shani, E Yunis, D Kufe, None, Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proceedings of the National Academy of Sciences. ,vol. 85, pp. 2320- 2323 ,(1988) , 10.1073/PNAS.85.7.2320
F. Sessa, E. Solcia, C. Capella, M. Bonato, A. Scarpa, G. Zamboni, N.S. Pellegata, G.N. Ranzani, F. Rickaert, G. Kl�ppel, Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients Virchows Archiv. ,vol. 425, pp. 357- 367 ,(1994) , 10.1007/BF00189573
C.G. Figdor, J. Hilkens, E. van de Wiel-van Kemenade, M.J.L. Ligtenberg, F. Buijs, C.J.M. Melief, H.L. Vos, A.J. de Boer, Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. Journal of Immunology. ,vol. 151, pp. 767- 776 ,(1993)