Blood-brain barrier permeability: regional alterations after acute and chronic administration of ethinyl estradiol.
作者： Y.Z. Ziylan , J.M. Lefauconnier , G. Bernard , J.M. Bourre
DOI: 10.1016/0304-3940(90)90621-F
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摘要: Abstract In this study we measured the effect of acute and chronic estrogen treatment on cerebrovascular permeability to sucrose inulin. Animals were subcutaneously injected once with 0.1 μg/rat ethinyl estradiol or daily same drug dose for 3 weeks. Control rats received amount arachis oil vehicle. Three weeks but not single injection produced significant increases in permeability-surface area product inulin almost all brain regions.
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