Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

摘要: Multiple sclerosis (MS) lesions are associated with infiltration of T lymphocytes and macrophages that appear to mediate myelin destruction gliosis (scarring). Mast cells located perivascularly in the brain, juxtaposed neurons, have been shown secrete vasoactive inflammatory mediators response neuropeptides direct nerve stimulation. previously identified MS lesions, activated by basic protein, can participate regulation blood-brain barrier permeability, as well destruction. Here, cerebrospinal fluid from patients controls other neurologic diseases was assayed for histamine, its major metabolite methylhistamine, specific mast cell marker tryptase. Histamine methylhistamine were not elevated MS. However, proteolytic enzyme tryptase significantly MS, suggesting activation may be involved pathophysiology this disease.