Influence of age and gender on the levels of histamine metabolites and pros-methylimidazoleacetic acid in human cerebrospinal fluid
作者： George D. Prell , Jai K. Khandelwal , R.Stanley Burns , Peter A. LeWitt , Jack Peter Green
DOI: 10.1016/0167-4943(91)90002-8
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摘要: The metabolites of histamine, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), were measured in cerebrospinal fluid (CSF) from 47 subjects with neurological disorders healthy controls. In lumbar CSF, concentrations these significantly correlated. Levels t-MH, t-MIAA their sum (which represents virtually all histamine metabolized brain) higher CSF older positively correlated age. Females had levels than males. Males pros-methylimidazoleacetic (p-MIAA), an isomer that is not a metabolite histamine. p-MIAA increased age among men. Analysis covariance indicated the subjects' health status little or no effect on age- sex-related differences analytes CSF; independent changes attributed to These results are contrast those age-related effects other aminergic transmitter suggest metabolic activity brain may increase
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