Effects of Cholecystokinin (CCK) on Gut Motility in the Stomachless Fish Ballan Wrasse (Labrus bergylta).

摘要: Cholecystokinin (CCK) is well-known as a key hormone that inhibits stomach emptying and stimulates midgut motility in gastric species. However, the function of CCK related to gut agastric fish, especially fish with short digestive tract such ballan wrasse, remains unknown. Here we present detailed description spatio-temporal quantification intestinal activity vitro comprising complete wrasse. We show modulates motility, having multiple effects on patterns depending location types contractions. reduced propagating contractions foregut, but it increased both non-propagating hindgut. also altered direction contractions, anterograde ripples slow The velocity was slowed down by CCK. amplitude standing ripples, did not alter presence CCKA receptor antagonist modulated responses wrasse intestines when exposed showed length stimulated empty gallbladder. Based our findings hypothesize CCK, mainly through receptor, optimize digestion absorption regulate evacuation found evidence modulation different from vertebrates. suggest this an evolutionary adaptation without stomach.