Effects of potential mediators of an intestinal brake mechanism on gut motility in Chinook salmon (Oncorhynchus tshawytscha)
作者： Leonard G. Forgan , Malcolm E. Forster
DOI: 10.1016/J.CBPC.2007.04.007
关键词: INT 、 Contractility 、 Oncorhynchus 、 Endocrinology 、 Cholecystokinin 、 Chemistry 、 Chinook wind 、 Gastrin 、 EC50 、 Internal medicine 、 Stomach
摘要: Abstract Potential humoral factors controlling an intestinal brake mechanism in Chinook salmon were characterised terms of their effect on frequency and amplitude spontaneous contractions gastrointestinal (GI) rings. Concentration–response curves gut contractility produced for cholecystokinin-8 (CCK-8), gastrin-1, glucagon-like peptide-1 (GLP-1) 5-hydroxytryptamine (5-HT) using rings from cardiac stomach (CS), pyloric (PY), sphincter (Psp) intestine (Int). Calculated log10 molar (M) EC50 values CCK-8 (n = 7) were: CS – 8.15 ± 0.90, PY – 7.88 ± 0.48, Psp – 8.98 ± 0.68, Int – 8.93 ± 0.64. Log10 M calculated gastrin 1 – 12.45 ± 0.66, – 12.55 ± 0.63, – 9.35 ± 0.78, – 12.69 ± 1.12. 5-HT (n = 6) – 4.78 ± 1.05 – 6.18 ± 1.14. GLP – 1 (n = 4) no response any the tissues examined. Spontaneous contractions, measured as spikes per minute peak force generated also each hormone-tissue combination. The greatest mass-specific force, with generating least force. Dilutions serum fish diagnosed gastric dilation air sacculitis (GDAS + ve) increased compared to controls − ve).
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