Revisiting CB1 Receptor as Drug Target in Human Melanoma
作者： István Kenessey , Balázs Bánki , Ágnes Márk , Norbert Varga , József Tóvári
DOI: 10.1007/S12253-012-9515-Y
关键词:
摘要: Previous studies have indicated the antitumoral effect of human melanocytes, melanoma cell lines expressing CB1 receptor (CB1), and peritumoral administration endocannabinoids. In present study, we systematically screened several for expression CNR1 demonstrated transcription authentic gene. The product CNR1, protein, was found localized to membrane as well cytoskeleton. Further, studied expressed functional since physiological synthetic ligands, anandamide (AEA), Met-F-AEA, ACEA AM251 showed a wide range biological effects in vitro, example anti-proliferative, proapoptotic anti-migratory. More importantly, our revealed that systemic stable agonist, ACEA, into SCID mice specifically inhibited liver colonization cells. Since therapeutic options patients are still very limited, endocannabinoid-CB1 system may offer novel target.
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