Ultrafiltration reduces blood transfusions following cardiac surgery: A meta-analysis.

摘要: Background Although used routinely in pediatric patients, ultrafiltration techniques that reverse hemodilution are infrequently adults. Data from small, unblinded clinical trials suggest the use of can reduce inflammatory mediators, improve cardiac function, and hemodilution. We conducted a meta-analysis randomized to evaluate effects on blood transfusions loss following adult surgery. Methods Medline, EMBASE, Cochrane databases were searched controlled evaluating modified and/or conventional ultrafiltration, meeting pre-determined selection criteria, obtained. Quality evaluation data extraction performed by two independent observers blinded study source. Random models determine pooled effect estimates sources heterogeneity explored using meta-regression. Results One hundred thirty studies screened 10 1004 patients (control, n = 495; 509) identified which only double-blinded. The was associated with reduction postoperative (weighted mean difference [95% CI] -0.73 units [-1.16, -0.31]; p 0.001). This greater ultrafiltration. Use also reduced bleeding (-70 ml, [-118, -21]; 0.005), driven primarily rather than Conclusions is significant as well adults undergoing efficacy cost-effectiveness conservations strategy should be evaluated large, randomized, double-blinded study.