Evaluation of a Neuraminidase Detection Assay for the Rapid Detection of Influenza A and B Virus in Children

摘要: A prototype version of a new diagnostic assay for influenza and B (Zstat Flu™) based on detection viral neuraminidase was evaluated compared to culture in 196 clinical samples. Children with respiratory illnesses were prospectively at pediatrician's office large children's hospital using the performed secretions. Influenza virus isolated from 51 samples 83 positive by assay. When sensitivity 96%, specificity 77%, predictive value 59%, negative 98%. Testing laboratory pure cultures bacteria non-influenza viruses frequently found tract showed 0% cross-reactivity 100% vitro. This provided useful information preliminary diagnosis infections appears be suitable both point-of-care use physician's rapid virology laboratory. The high makes it particularly as screening test exclusion infections. To confirm exclude false-positive result, well determine type, may considered.