Factors associated with improved survival among older colorectal cancer patients in the US: a population-based analysis.

摘要: The purpose of this study was to estimate the relative impact changes in demographics, stage at detection, treatment mix, and medical technology on 5-year survival among older colorectal cancer (CRC) patients. We selected patients diagnosed with CRC between 1992 2000 from SEER-Medicare database followed them through 2005. Trends demographic characteristics, detection initial mix were evaluated descriptively. Separate multivariate logistic regression models for colon (CC) rectal (RC) estimated isolate independent effects these factors along technological change (proxied by cohort year) survival. Our sample included 37,808 CC 13,619 RC (combined mean ± SD age: 77.2 7.0 years; 55% female; 87% white). In recent years, more Stage I fewer Stages II IV, III. later years slightly somewhat better Charlson scores likely be female, Northeast, areas higher average education levels. Surgery alone common while combined surgery, chemotherapy, radiotherapy Between 2000, observed improved 43.0% 46.3% 39.4% 42.2% Multivariate regressions indicate that had significantly greater odds than those (OR: 1.35 CC, 1.38 RC). decomposition suggests early little survival; rather, improvements (e.g., new technologies or effective use existing technologies) changing demographics responsible largest share 2000. Technological advances patient during period.