The myeloperoxidase-463 G>A polymorphism influences risk of colorectal cancer in southern China: a case-control study.
作者： Mei-Lin Wang , Yuan Qin , Ying Li , Huan-Feng Zhu , Xin-En Huang
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摘要: Objective: Oxidative stress may be involved in colorectal carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). We hypothesized the MPO -463 locus polymorphism might therefore contribute to genetic susceptibility adenomas. Methods: RFLP-PCR analysis identified genotypes 325 Chinese adenomas cases and 345 controls matched by age, sex, smoking status, alcohol use. An epidemiological interview elicited detailed information on demographic data lifestyle characteristics. Results: Individuals with a GA/AA genotype had significantly lower risk of cancer (adjusted OR = 0.57, 95% CI, 0.41-0.79) than those GG genotype. On stratification analysis, decreased was more pronounced among older subjects 0.56, 0.39-0.81), males (0.47, 0.33-0.68), smokers (0.54, 0.35-0.85), ever-drinkers (0.44, 0.27-0.71). Conclusion: For similar level exposure established carcinogens, individuals A-allele appear have reduced southern population, especially subjects, men, smokers, ever-drinkers.
koreascience.or.kr参考文章(28)
Halla Skuladottir, Herman Autrup, Judith Autrup, Anne Tjoenneland, Kim Overvad, David Ryberg, Aage Haugen, Jørgen H. Olsen, Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years A pooled study of lung cancer patients in Denmark and Norway Lung Cancer. ,vol. 48, pp. 187- 199 ,(2005) , 10.1016/J.LUNGCAN.2004.10.013
Jiang He, Dongfeng Gu, Xigui Wu, Kristi Reynolds, Xiufang Duan, Chonghua Yao, Jialiang Wang, Chung-Shiuan Chen, Jing Chen, Rachel P. Wildman, Michael J. Klag, Paul K. Whelton, Major Causes of Death among Men and Women in China The New England Journal of Medicine. ,vol. 353, pp. 1124- 1134 ,(2005) , 10.1056/NEJMSA050467
S J McKenzie, M S Baker, G D Buffinton, W F Doe, Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. Journal of Clinical Investigation. ,vol. 98, pp. 136- 141 ,(1996) , 10.1172/JCI118757
Matthew Whiteman, Jeremy P.E. Spencer, Andrew Jenner, Barry Halliwell, Hypochlorous acid-induced DNA base modification: potentiation by nitrite: biomarkers of DNA damage by reactive oxygen species. Biochemical and Biophysical Research Communications. ,vol. 257, pp. 572- 576 ,(1999) , 10.1006/BBRC.1999.0448
Matthew Whiteman, Andrew Jenner, Barry Halliwell, Hypochlorous Acid-Induced Base Modifications in Isolated Calf Thymus DNA Chemical Research in Toxicology. ,vol. 10, pp. 1240- 1246 ,(1997) , 10.1021/TX970086I
Sonny L. Johansson, Samuel M. Cohen, Epidemiology and etiology of bladder cancer Seminars in Surgical Oncology. ,vol. 13, pp. 291- 298 ,(1997) , 10.1002/(SICI)1098-2388(199709/10)13:5<291::AID-SSU2>3.0.CO;2-8
Aurélie Moskal, Teresa Norat, Pietro Ferrari, Elio Riboli, Alcohol intake and colorectal cancer risk: A dose–response meta‐analysis of published cohort studies International Journal of Cancer. ,vol. 120, pp. 664- 671 ,(2007) , 10.1002/IJC.22299
Matthew B. Schabath, Margaret R. Spitz, Waun K. Hong, George L. Delclos, Wanda F. Reynolds, Gary B. Gunn, Lawrence W. Whitehead, Xifeng Wu, A myeloperoxidase polymorphism associated with reduced risk of lung cancer Lung Cancer. ,vol. 37, pp. 35- 40 ,(2002) , 10.1016/S0169-5002(02)00034-X
M. Steenport, H. Eom, M. Uezu, J. Schneller, R. Gupta, Y. Mustafa, R. Villanueva, E. Straus, R. Raffaniello, Association of polymorphisms in myeloperoxidase and catalase genes with precancerous changes in the gastric mucosa of patients at inner-city hospitals in New York Oncology Reports. ,vol. 18, pp. 235- 240 ,(2007) , 10.3892/OR.18.1.235
Shiho Ohnishi, Mariko Murata, Shosuke Kawanishi, DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis. Cancer Letters. ,vol. 178, pp. 37- 42 ,(2002) , 10.1016/S0304-3835(01)00812-6